Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunity
Identifieur interne : 002A40 ( Main/Exploration ); précédent : 002A39; suivant : 002A41Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunity
Auteurs : Lanying Du [États-Unis] ; Guangyu Zhao [République populaire de Chine] ; Chris C. S. Chan [République populaire de Chine] ; Shihui Sun [République populaire de Chine] ; Min Chen [République populaire de Chine] ; Zhonghua Liu [États-Unis] ; Hongxiang Guo [États-Unis] ; Yuxian He [États-Unis] ; Yusen Zhou [République populaire de Chine] ; Bo-Jian Zheng [République populaire de Chine] ; Shibo Jiang [États-Unis]Source :
- Virology [ 0042-6822 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Clonage moléculaire, Escherichia coli (génétique), Expression des gènes, Femelle, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Glycoprotéines membranaires (immunologie), Lignée cellulaire, Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (immunologie), Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Tests de neutralisation, Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Vaccins sous-unitaires (génétique), Vaccins sous-unitaires (immunologie), Vaccins synthétiques (génétique), Vaccins synthétiques (immunologie), Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- génétique : Escherichia coli, Glycoprotéines membranaires, Protéines de l'enveloppe virale, Vaccins antiviraux, Vaccins sous-unitaires, Vaccins synthétiques, Virus du SRAS.
- immunologie : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Vaccins sous-unitaires, Vaccins synthétiques, Virus du SRAS.
- sang : Anticorps antiviraux.
- Animaux, Clonage moléculaire, Expression des gènes, Femelle, Glycoprotéine de spicule des coronavirus, Lignée cellulaire, Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère, Tests de neutralisation.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (blood), Cell Line, Cloning, Molecular, Escherichia coli (genetics), Female, Gene Expression, Insecta, Membrane Glycoproteins (genetics), Membrane Glycoproteins (immunology), Mice, Mice, Inbred BALB C, Neutralization Tests, SARS Virus (genetics), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), Spike Glycoprotein, Coronavirus, Vaccines, Subunit (genetics), Vaccines, Subunit (immunology), Vaccines, Synthetic (genetics), Vaccines, Synthetic (immunology), Viral Envelope Proteins (genetics), Viral Envelope Proteins (immunology), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , blood : Antibodies, Viral.
- genetics : Escherichia coli, Membrane Glycoproteins, SARS Virus, Vaccines, Subunit, Vaccines, Synthetic, Viral Envelope Proteins, Viral Vaccines.
- chemical , immunology : Membrane Glycoproteins, SARS Virus, Severe Acute Respiratory Syndrome, Vaccines, Subunit, Vaccines, Synthetic, Viral Envelope Proteins, Viral Vaccines.
- prevention & control : Severe Acute Respiratory Syndrome.
- Animals, Cell Line, Cloning, Molecular, Female, Gene Expression, Insecta, Mice, Mice, Inbred BALB C, Neutralization Tests, Spike Glycoprotein, Coronavirus.
Abstract
Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease. The potential recurrence of the disease from animal reservoirs highlights the significance of development of safe and efficient vaccines to prevent a future SARS epidemic. In this study, we expressed the recombinant receptor-binding domain (rRBD) in mammalian (293T) cells, insect (Sf9) cells, and
Url:
DOI: 10.1016/j.virol.2009.07.018
PubMed: 19683779
PubMed Central: 2753736
Affiliations:
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Le document en format XML
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</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
<term>Vaccines, Subunit</term>
<term>Vaccines, Synthetic</term>
<term>Viral Envelope Proteins</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Cloning, Molecular</term>
<term>Female</term>
<term>Gene Expression</term>
<term>Insecta</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Neutralization Tests</term>
<term>Spike Glycoprotein, Coronavirus</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Clonage moléculaire</term>
<term>Expression des gènes</term>
<term>Femelle</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Lignée cellulaire</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Tests de neutralisation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease. The potential recurrence of the disease from animal reservoirs highlights the significance of development of safe and efficient vaccines to prevent a future SARS epidemic. In this study, we expressed the recombinant receptor-binding domain (rRBD) in mammalian (293T) cells, insect (Sf9) cells, and <italic>E. coli</italic>
, respectively, and compared their immunogenicity and protection against SARS-CoV infection in an established mouse model. Our results show that all rRBD proteins expressed in the above systems maintained intact conformation, being able to induce highly potent neutralizing antibody responses and complete protective immunity against SARS-CoV challenge in mice, albeit the rRBD expressed in 293T cells elicited stronger humoral immune responses with significantly higher neutralizing activity (<italic>P</italic>
< 0.05) than those expressed in Sf9 and <italic>E. coli</italic>
cells. These results suggest that all three rRBDs are effective in eliciting immune responses and protection against SARS-CoV and any of the above expression systems can be used for production of rRBD-based SARS subunit vaccines. Preference will be given to rRBD expressed in mammalian cells for future evaluation of the vaccine efficacy in a non-human primate model of SARS because of its ability to refold into a native conformation more readily and to induce higher level of neutralizing antibody responses than those expressed in <italic>E. coli</italic>
and insect cells.</p>
</div>
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</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>État de New York</li>
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</affiliations>
</record>
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